Larnell、Luanne带着他们的疯狂搞笑再次回归，由于吸烟引起的怪异副作用，他们前往南美寻求治疗。在深山丛林里，他们遇到了致命的危险……
An insane man first loves then grows to hate his neighbor, an old man whose penetrating gaze unnerves the insane man. He plans a perfect crime and executes it one night. The next day, two officers knock on the insane man's door, investigating a shriek heard in the night. The insane man invites them in, answers their questions, and submits to an examination of his eyes by one of the officers, who proclaims him innocent. The insane man invites them to stay and relax awhile, then regales them with his theories of crime. His heart begins to beat louder. Angles on the set are skewed to suggest the man's internal disarray.
岸田智也（市原隼人）和佐藤葵（上野树里）在大学结识。二人非常合拍，葵还常常给智也出谋划策如何追女生。葵是独立电影制作小组的成员，她要在毕业前导演一部叫《THE END OF THE WORLD》的电影，于是决定选用智也当男主角。无奈毕业后，路开始分叉。葵引荐智也去了一间影视社工作，重遇那晚葵想说出对智也的情愫，然而终究没有开口。 葵不久飞往美国留学。正巧智也抬头，看到天空挂着彩虹。他兴奋地拍下，发送给相隔重洋的葵，但是却得到了葵飞机失事罹难的噩耗。亲人同学都悲伤不已，用她生前的电影去悼念逝者，在智也的心目中，葵也始终朦胧的牵动着他内心的爱。
